Ito A, Sugihara M
Hospital Pharmacy, Tokyo Women's Medical College, Japan.
Yakugaku Zasshi. 1991 Oct;111(10):606-11. doi: 10.1248/yakushi1947.111.10_606.
The relationship between dividing properties of the scored tablet and dynamic characteristics of the powder was investigated for proving the effects of physical characteristics of the powder on dividing properties of the scored tablet. Lactose, microcrystalline cellulose, corn starch, synthetic aluminum silicate and Perfiller were used as excipients. The dynamic characteristics of the powder, such as tensile strength (T), cohesive force (C), angle of friction (delta), flow factor (FF), shear index (n), C/T(K) and constants of Kawakita's equation of tapping compaction (a, 1/b) were measured. No correlations between coefficient of variation of divided tablet weight and each dynamic characteristics of the powder were found. However, from the result of the multiple regression analysis, multiple regression equation containing C and a as variables was obtained. Then a significant correlation was obtained between coefficient of variation of divided tablet weight and C/a, and also between logarithms of dividing strength of scored tablets and C/a. As a result, coefficient of variation of divided tablet weight decreased and dividing strength of scored tablets increased with decreasing C/a value.
为了证明粉末的物理特性对刻痕片分割性能的影响，研究了刻痕片的分割性能与粉末动态特性之间的关系。使用乳糖、微晶纤维素、玉米淀粉、合成硅酸铝和Perfiller作为辅料。测量了粉末的动态特性，如抗张强度（T）、内聚力（C）、摩擦角（δ）、流动因子（FF）、剪切指数（n）、C/T（K）以及卡瓦基塔敲击压实方程的常数（a，1/b）。未发现分割片重量变异系数与粉末的各动态特性之间存在相关性。然而，通过多元回归分析结果，得到了以C和a为变量的多元回归方程。然后，分割片重量变异系数与C/a之间以及刻痕片分割强度的对数与C/a之间均获得了显著相关性。结果，随着C/a值的降低，分割片重量变异系数减小，刻痕片的分割强度增加。
