Nelson J A, Schmiedl U
Department of Radiology, University of Washington, Seattle 98195.
Magn Reson Med. 1991 Dec;22(2):366-71; discussion 378. doi: 10.1002/mrm.1910220243.
The interest in tissue distribution of variously labeled or otherwise detectable natural and synthetic porphyrins and porphyrin derivatives dates back well over 60 years. Although a considerable interest in fluorescent tumor localization and therapy dominates the history of porphyrin biodistribution studies, many investigators have evaluated the diagnostic and therapeutic characteristics of porphyrins with radioactive, radiopaque, and paramagnetic qualities. In this paper, a review of the use of porphyrins as nuclear medicine, X-ray, and NMR contrast agents is presented.
对各种标记或其他可检测的天然和合成卟啉及卟啉衍生物的组织分布的研究兴趣可以追溯到60多年前。尽管对荧光肿瘤定位和治疗的浓厚兴趣主导了卟啉生物分布研究的历史，但许多研究人员已经评估了具有放射性、不透X射线和顺磁性的卟啉的诊断和治疗特性。本文综述了卟啉作为核医学、X射线和核磁共振造影剂的应用。
