Müller N, Schiller P, Ackenheil M
Department of Psychiatry, University of Munich, Germany.
Pharmacopsychiatry. 1991 Nov;24(6):225-8. doi: 10.1055/s-2007-1014472.
In a retrospective study, the bilirubin plasma concentrations of every patient admitted to the Psychiatric Hospital were collected. Patients suffering from liver disease, substance abuse, overt hemolysis, or increased liver enzymes were excluded. Schizophrenics showed a significantly higher incidence of hyperbilirubinemia than patients suffering from other psychiatric disorders. This phenomenon seems to be independent of drug usage and therefore points to a relationship between hyperbilirubinemia and schizophrenic psychosis. Hypothetic explanations, such as a possible genetic disposition for Gilbert Syndrome, an increased vulnerability of red-cell membranes, and the role of estrogens in schizophrenic patients, are discussed.
在一项回顾性研究中，收集了精神病医院收治的每位患者的血浆胆红素浓度。排除患有肝病、药物滥用、明显溶血或肝酶升高的患者。精神分裂症患者的高胆红素血症发病率明显高于其他精神疾病患者。这种现象似乎与药物使用无关，因此表明高胆红素血症与精神分裂症精神病之间存在关联。文中讨论了一些假设性解释，如吉尔伯特综合征可能的遗传易感性、红细胞膜易损性增加以及雌激素在精神分裂症患者中的作用。
