Uehara T, Izumo T, Kishi K, Takayama S, Kasuga T
Department of Pathology, Saitama Cancer Center, Japan.
Acta Pathol Jpn. 1991 Oct;41(10):751-6. doi: 10.1111/j.1440-1827.1991.tb03347.x.
Stromal melanocytic foci (SMF) of the uterine cervix, which are known as extracutaneous blue nevus, were examined in step sections of the cervix. A total of 189 uterine specimens surgically excised for leiomyoma, adenomyosis etc., were studied. The over-all incidence of SMF of the cervix was 28.6% (54/189 cases). The incidence of these lesions increased with age, and they were most prevalent in the sixth decade of life (12/30 cases, 40%). SMF were presented more often in the anterior wall than in the posterior wall. Most of the lesions were less than 1 mm in size. No case of SMF demonstrated expansive tumorous growth. Six of 54 cases of SMF displayed consecutive spread of SMF in almost all step sections of the cervix. The histological findings confirmed that SMF of the cervix is quite common existence among Japanese women. It is speculated that the mucosal region near the skin and/or cutaneous region near the mucosa may have stromal melanocytosis; malignant melanoma could develop from SMF of the cervix, which did not have junctional activity because of stromal melanocytic origin.
子宫颈的基质黑素细胞灶（SMF），即所谓的皮肤外蓝痣，在子宫颈连续切片中进行了检查。共研究了189例因平滑肌瘤、子宫腺肌病等而手术切除的子宫标本。子宫颈SMF的总体发生率为28.6%（54/189例）。这些病变的发生率随年龄增加，在60岁时最为常见（12/30例，40%）。SMF在前壁的出现频率高于后壁。大多数病变大小小于1毫米。没有SMF病例表现出膨胀性肿瘤生长。54例SMF中有6例在子宫颈几乎所有连续切片中都显示出SMF的连续蔓延。组织学结果证实，子宫颈SMF在日本女性中相当常见。推测皮肤附近的黏膜区域和/或黏膜附近的皮肤区域可能存在基质黑素细胞增多；子宫颈SMF可发展为恶性黑色素瘤，因其起源于基质黑素细胞而不具有交界活性。
