Lamka J, Gallová S
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové.
Physiol Res. 1991;40(5):543-8.
The authors studied ortho-I-hippurate kinetics in the blood and central lymph in two groups of intact rats and three groups of animals with induced pathological states (cirrhosis, uraemia, malabsorption). A differentiated lipid concentration in the central lymph was induced in intact animals by depriving them of food (the unfed group) or allowing them food (the fed group) before the experiment. All the hippurate kinetic parameters, including lymphatic bioavailability (FL), in the fed group were very close to those in the unfed group, which was also used as the control for the groups with induced pathological states. Cirrhosis, uraemia and malabsorption altered the blood and lymphatic kinetic parameters in many cases, but the changes mostly followed a parallel course so that FL was maintained (except in the uraemia group, in which it fell).
作者研究了两组完整大鼠以及三组诱导出病理状态（肝硬化、尿毒症、吸收不良）的动物的血液和中央淋巴中的邻碘马尿酸盐动力学。在实验前，通过不给完整动物喂食（未喂食组）或允许其进食（喂食组），在中央淋巴中诱导出不同的脂质浓度。喂食组中所有马尿酸盐动力学参数，包括淋巴生物利用度（FL），都与未喂食组非常接近，未喂食组也用作诱导病理状态组的对照。在许多情况下，肝硬化、尿毒症和吸收不良改变了血液和淋巴动力学参数，但变化大多呈平行趋势，因此FL得以维持（尿毒症组除外，该组FL下降）。
