Matolcsy A, Izer I, Magyarlaki T, Baranyay F
Department of Pathology, University Medical School of Pécs, Hungary.
Haematologia (Budap). 1991;24(1):27-37.
Enzyme negative blast cells from 27 patients with chronic myeloproliferative disorders (CMPDs) in blastic transformation were analysed with a panel of monoclonal antibodies (MoAbs). According to morphologic features of the bone marrow and laboratory data, the 27 cases were divided into 8 cases of myelofibrosis (MF), 3 cases of chronic megakaryocytic granulocytic myelosis (CMGM) and 16 cases of chronic myeloid leukaemia (CML). Of the 27 cases, 23 showed a positive reaction with myeloid MoAbs, but in 12 cases expressing myeloid markers, megakaryocytic, monocytic or lymphoid cell features were also detected. In 7 cases of MF, 1 case of CMGM and 1 case of CML a bilineage, myelo-megakaryocytoid immunophenotype of peripheral blast cells was seen. Of the 4 patients with CML expressing lymphoid markers, 2 showed early B-cell, 1 T-cell surface antigens, and 1 both myeloid and early B-cell features. In this group of cytochemically immature blastic transformation of CMPD, only 1 case was termed "undifferentiated" blastic transformation.
应用一组单克隆抗体（MoAb）对27例处于原始细胞转化期的慢性骨髓增殖性疾病（CMPD）患者的酶阴性原始细胞进行了分析。根据骨髓形态学特征和实验室数据，将这27例患者分为8例骨髓纤维化（MF）、3例慢性巨核细胞粒细胞性骨髓增生症（CMGM）和16例慢性髓性白血病（CML）。在这27例患者中，23例对髓系MoAb呈阳性反应，但在12例表达髓系标志物的患者中，也检测到了巨核细胞、单核细胞或淋巴细胞特征。在7例MF、1例CMGM和1例CML患者中，外周血原始细胞呈现双系、髓-巨核细胞样免疫表型。在4例表达淋巴细胞标志物的CML患者中，2例表现为早期B细胞、1例表现为T细胞表面抗原，1例同时具有髓系和早期B细胞特征。在这组细胞化学不成熟的CMPD原始细胞转化病例中，仅1例被称为“未分化”原始细胞转化。
