• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[Fractionation of eukaryotic DNA in a pulsed electrical field. II. Discrete DNA fragments and level of structural organization of chromatin].

作者信息

Solov'ian V T, Andreev I O, Kunakh V A

出版信息

Mol Biol (Mosk). 1991 Nov-Dec;25(6):1483-91.

PMID:1813795
Abstract

The data presented confirm the possibility of enzymatic formation of discrete DNA-fragments appearing during fractionation of nuclear DNA by FIGE. Teniposide-dependent pattern of DNA-fragments as well as occurrence of protein-linked DNA breaks suggest that discrete cleavage of intact nuclear DNA is modulated by DNA topoisomerase II. The possible relationship between discrete DNA-fragments and the higher order chromatin folding are discussed.

摘要

相似文献

1
[Fractionation of eukaryotic DNA in a pulsed electrical field. II. Discrete DNA fragments and level of structural organization of chromatin].
Mol Biol (Mosk). 1991 Nov-Dec;25(6):1483-91.
2
[Fractionation of eukaryotic DNA in a pulsating electrical field. I. Detection and properties of discrete DNA fragments].[真核生物DNA在脉动电场中的分级分离。I. 离散DNA片段的检测与特性]
Mol Biol (Mosk). 1991 Jul-Aug;25(4):1071-9.
3
Structural domains of plant nuclear DNA as a constitutive component of the topoisomerase II/DNA complex.
Acta Biochim Pol. 1995;42(2):201-4.
4
Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility.果蝇染色质中拓扑异构酶II DNA切割的药物特异性位点：异质性定位与可逆性
Cancer Res. 1996 Apr 15;56(8):1855-62.
5
Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements.在喹诺酮类药物CP - 115,953存在的情况下对真核生物拓扑异构酶II切割位点进行分析，揭示了药物依赖性和非依赖性识别元件。
Mol Pharmacol. 1995 Aug;48(2):238-49.
6
Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons.通过比较三种不同毒物增强的DNA断裂来确定拓扑异构酶II活性的基因组位点。
J Mol Biol. 1999 Jan 15;285(2):545-54. doi: 10.1006/jmbi.1998.2330.
7
Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis.药物诱导凋亡中观察到的高阶染色质片段化机制的研究。
Mol Pharmacol. 1995 May;47(5):986-96.
8
Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.
Cancer Res. 1991 Feb 15;51(4):1078-85.
9
Disassembly of genome of higher eukaryotes: pulsed-field gel electrophoretic study of initial stages of chromatin and DNA degradation in rat liver and thymus nuclei by VM-26 and selected proteases.
Comp Biochem Physiol B Biochem Mol Biol. 1998 Oct;121(2):145-51. doi: 10.1016/s0305-0491(98)10082-2.
10
Pulsed-field gel electrophoresis analysis of higher-order chromatin structures of Zea mays. Highly methylated DNA in the 50 kb chromatin structure.玉米高阶染色质结构的脉冲场凝胶电泳分析。50 kb染色质结构中高度甲基化的DNA。
Plant Mol Biol. 1993 Mar;21(5):847-57. doi: 10.1007/BF00027116.