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[小鼠经胎盘诱导肺肿瘤过程中c-Ki-ras癌基因第61位密码子的突变及其在自发肿瘤和诱导肿瘤中的差异]

[Mutations in the 61st codon of the c-Ki-ras oncogene during transplacental lung tumor induction in mice and their difference in spontaneous and induced tumors].

作者信息

Loktionov A S

出版信息

Mol Biol (Mosk). 1991 Nov-Dec;25(6):1517-25.

PMID:1813798
Abstract

DNA isolated from lung and liver tumor which were induced in CD-1 mice by transplacental treatment with 7,12-dimethylbenz(a)anthracene (DMBA) or developed spontaneously was analyzed for the presence of Ha- and Ki-ras oncogene codon 61 mutations. The A to T transversions at the second position of Ha-ras codon 61 were revealed only in liver tumors of DMBA-exposed animals, whereas only Ki-ras mutations occurred in both spontaneous and induced tumors of the lung. A to T mutations at the second position of Ki-ras codon 61 or non-identified yet mutations at the third position of the same codon were shown to be related to DMBA treatment. Thus both tissue and carcinogen specificity of ras oncogene activation was clearly demonstrated.

摘要

对通过经胎盘给予7,12 - 二甲基苯并(a)蒽（DMBA）诱导或自发产生于CD - 1小鼠的肺和肝肿瘤中分离出的DNA，分析其Ha - 和Ki - ras癌基因密码子61突变的存在情况。Ha - ras密码子61第二位的A到T颠换仅在暴露于DMBA的动物的肝肿瘤中被发现，而在肺的自发和诱导肿瘤中仅发生Ki - ras突变。Ki - ras密码子61第二位的A到T突变或同一密码子第三位尚未确定的突变被证明与DMBA处理有关。因此，ras癌基因激活的组织和致癌物特异性得到了明确证明。

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