Kuchna I, Kozłowski P B
Laboratory of Developmental Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Neuropatol Pol. 1991;29(1-2):103-8.
We presented the case of a 78-year-old man with mental retardation and spastic paraparesis diagnosed early in life as cerebral palsy. Six years prior to demise he had post-traumatic subdural hematoma, which was removed surgically. The neuropathological examination revealed the sequelae of the recent trauma, superimposed on the extensive old lesions. Cavitary changes in the periventricular white matter and cortical ulegyria in the border zones of the major cerebral arteries vascularization were characteristic of perinatal hypoxic-ischemic lesions. Peculiar in the ulegyria were extensive areas with numerous corpora amylacea adjacent to the areas of fibrillar and cellular gliosis. Another sequelae of involution processes was the atrophy of brain hemispheres (secondary microcephaly). The case appears to be an example of the late degenerative involution changes developing on the background of lesions originated from the perinatal period.
我们报告了一例78岁男性病例，该患者自幼被诊断为脑瘫，有智力发育迟缓及痉挛性截瘫症状。在其去世前六年，他曾患创伤后硬膜下血肿，并接受了手术清除。神经病理学检查显示，近期创伤的后遗症叠加在广泛的陈旧性病变之上。脑室周围白质的空洞性改变以及大脑主要动脉血管化边缘区的皮质脑回形成不良是围产期缺氧缺血性病变的特征。脑回形成不良的特殊之处在于，在纤维性和细胞性胶质增生区域附近有大量淀粉样体的广泛区域。萎缩过程的另一个后遗症是脑半球萎缩（继发性小头畸形）。该病例似乎是在围产期起源的病变背景下发生的晚期退行性萎缩变化的一个例子。
