Waśkiewicz J, Wałajtys-Rode E, Rafałowska U
Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Neuropatol Pol. 1991;29(1-2):79-85.
Adult male Wistar rats were submitted to normobaric hyperoxygenation for 1 and 4 hours, then brain synaptosomes were isolated and uptake and release of the histamine precursor - histidine (His), histamine (HA) level and His metabolizing enzymes activities were measured. This uptake in hyperoxic synaptosomes was inhibited by about 20%. After 1-hour hyperoxia, a tendency towards an increase of the HA level, but a significant increase histidine decarboxylase (HD) and histamine methyltransferase (HMT) activities were observed. Four-hour hyperoxia caused a decrease of both the HA level and the activities of both enzymes, especially HMT. The changes were reversed in 1-hour posthyperoxic recovery, except for histidine uptake which remained inhibited.
成年雄性Wistar大鼠接受常压高氧处理1小时和4小时，然后分离脑突触体并测量组胺前体 - 组氨酸（His）的摄取和释放、组胺（HA）水平以及His代谢酶活性。高氧突触体中的这种摄取受到约20%的抑制。高氧处理1小时后，观察到HA水平有增加的趋势，但组胺脱羧酶（HD）和组胺甲基转移酶（HMT）活性显著增加。高氧处理4小时导致HA水平和两种酶的活性均下降，尤其是HMT。在高氧后1小时的恢复过程中，这些变化被逆转，除了组氨酸摄取仍受到抑制。
