饥饿与发育对大鼠肝脏线粒体乙酰乙酰辅酶A硫解酶的影响。
Effects of starvation and development on mitochondrial acetoacetyl-coenzyme A thiolase of rat liver.
作者信息
Reed W D, Ozand P T, Tildon J T, Cornblath M
出版信息
Biochem J. 1977 Apr 15;164(1):27-32. doi: 10.1042/bj1640027.
Abstract
The activity of the putative ketogenic beta-oxoacyl-CoA thiolase from mitochondria of rat liver increases with starvation, during neonatal life, and after the injection of glucagon. These changes are associated with alteration in ketonaemia. The changes in activities of this species of thiolase are not associated with significant alterations in the apparent affinity (Km) for the ketogenic substrate, acetyl-CoA. These results support a role for thiolase in the regulation of ketogenesis.
摘要
来自大鼠肝脏线粒体的假定生酮β-氧代酰基辅酶A硫解酶的活性，在饥饿期间、新生期以及注射胰高血糖素后会增加。这些变化与酮血症的改变相关。这种硫解酶活性的变化与对生酮底物乙酰辅酶A的表观亲和力（Km）的显著改变无关。这些结果支持硫解酶在酮体生成调节中发挥作用。
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