HIV infection can produce a clinical syndrome and immunologic changes similar to those seen in SS. HIV infection can occasionally result in an SS-like disease but without the formation of antibodies to Ro(SS-A) or La(SS-B). Could this mean that a retrovirus yet to be discovered is responsible for the autoimmune exocrinopathy known as SS? Evidence to date is circumstantial, based on antibodies to a retroviral protein (p24). The idea that retroviruses act in a genetically susceptible host to cause SS is a reasonable hypothesis. Syphilis and Lyme disease are both models where infectious organisms cause chronic multi-system disease. The virus of SS need not be a foreign invader but could be an endogenous retrovirus contained within our own genetic material (10, 11). More investigation is needed to exploit the research opportunities that have appeared in clinical immunology since the AIDS epidemic first appeared.
人类免疫缺陷病毒（HIV）感染可产生与干燥综合征（SS）相似的临床综合征和免疫变化。HIV感染偶尔会导致类似SS的疾病，但不会形成抗Ro（SS-A）或La（SS-B）抗体。这是否意味着一种尚未被发现的逆转录病毒是导致被称为SS的自身免疫性外分泌病的原因？迄今为止的证据都是间接的，基于针对一种逆转录病毒蛋白（p24）的抗体。逆转录病毒在遗传易感宿主中引发SS的观点是一个合理的假设。梅毒和莱姆病都是感染性生物体导致慢性多系统疾病的例子。SS病毒不一定是外来入侵者，也可能是包含在我们自身遗传物质中的内源性逆转录病毒（10, 11）。自艾滋病流行首次出现以来，临床免疫学中出现了一些研究机会，需要进行更多的调查来加以利用。
