Diana M, Mereu G, Mura A, Fadda F, Passino N, Gessa G
Dipartimento di Neuroscienze B.B. Brodie, Università di Cagliari, Italy.
Brain Res. 1991 Dec 6;566(1-2):208-11. doi: 10.1016/0006-8993(91)91700-b.
In unanesthetized rats the intravenous (i.v.) administration of gamma-hydroxybutyric acid (GHB) at the doses of 50-400 mg/kg produced a dose-related stimulation (10-56%) of the firing rate of dopaminergic (DA) neurons in the pars compacta of the substantia nigra. Doses of 1000 and 1500 mg/kg inhibited the firing rate almost completely. In unanesthetized rats the intraperitoneal injection of GHB at the dose of 750 mg/kg produced a brief initial stimulation (23%) followed by a modest reduction in the firing rate (29%). On the other hand, in chloral hydrate-anesthetized rats the i.v. administration of GHB at cumulative doses of up to 200 mg/kg failed to modify the firing rate of DA neurons, while a cumulative dose of 400 mg/kg suppressed neuronal firing. The results indicate that sub-anesthetic doses of GHB stimulate the firing rate of DA neurons in unanesthetized rats.
在未麻醉的大鼠中，静脉注射剂量为50 - 400毫克/千克的γ-羟基丁酸（GHB）会使黑质致密部多巴胺能（DA）神经元的放电频率产生与剂量相关的刺激（10 - 56%）。1000毫克/千克和1500毫克/千克的剂量几乎完全抑制了放电频率。在未麻醉的大鼠中，腹腔注射750毫克/千克的GHB会产生短暂的初始刺激（23%），随后放电频率适度降低（29%）。另一方面，在水合氯醛麻醉的大鼠中，静脉注射累计剂量高达200毫克/千克的GHB未能改变DA神经元的放电频率，而累计剂量400毫克/千克则抑制了神经元放电。结果表明，亚麻醉剂量的GHB会刺激未麻醉大鼠中DA神经元的放电频率。
