啮齿动物与人类大脑区域葡萄糖代谢的比较

Regional cerebral glucose metabolism compared in rodents and humans.

作者信息

Blin J, Ray C A, Chase T N, Piercey M F

机构信息

Experimental Therapeutics Branch, NINDS, NIH Bethesda, MD.

出版信息

Brain Res. 1991 Dec 24;568(1-2):215-22. doi: 10.1016/0006-8993(91)91400-u.

DOI:10.1016/0006-8993(91)91400-u

PMID:1814569

Abstract

In order to compare regional brain glucose metabolism in rats and humans, this parameter was measured using Sokoloff's deoxyglucose method in rats, and positron emission tomography with magnetic resonance imaging in humans. An atlas of cerebral regions of interest common to both species was developed to facilitate the evaluation of the relationship in regional values. We found among the regions studied a significant positive correlation in their metabolic values (r = 0.72, P less than 0.001) and coefficients of variation (r = 0.59, P less than 0.01) suggesting that regional brain glucose consumption is comparable between rat and human. Results of this study support the view that rat and human brain may be phylogenetically linked functionally as well as anatomically.

摘要

为了比较大鼠和人类大脑区域的葡萄糖代谢情况，采用索科洛夫脱氧葡萄糖法测量大鼠的这一参数，而人类则使用正电子发射断层扫描与磁共振成像技术。开发了一个两种物种共有的大脑感兴趣区域图谱，以方便评估区域值之间的关系。我们发现在所研究的区域中，它们的代谢值存在显著正相关（r = 0.72，P < 0.001）以及变异系数也存在显著正相关（r = 0.59，P < 0.01），这表明大鼠和人类大脑区域的葡萄糖消耗具有可比性。本研究结果支持这样一种观点，即大鼠和人类大脑在功能以及解剖结构上可能在系统发育上存在联系。