Gaignage P, Lognay G, Bosson D, Vertongen D, Dreze P, Marlier M, Severin M
Department of General and Organic Chemistry, Faculty of Agricultural Sciences, Gembloux, Belgium.
Eur J Drug Metab Pharmacokinet. 1991 Jul-Sep;16(3):219-21. doi: 10.1007/BF03189963.
Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54 h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml. Tritiated dexamethasone was also administered twice to an another young bull for metabolite investigation. The elapsed time required to recover, in plasma, half of the radioactivity injected was 8.8 h. Radioactivity recovery in the urine reached 36.4% and 22.6% for the first and the second injections respectively.
磷酸地塞米松（DXM-PHO）是一种酯，它能被牛迅速水解，地塞米松（DXM）的血浆半衰期为5.16小时。已经证明，注射DXM-PHO 54小时后，DXM浓度低于0.1毫克/毫升。还对另一头年轻公牛两次给予氚标记的地塞米松以进行代谢物研究。血浆中放射性恢复一半所需的时间为8.8小时。第一次和第二次注射后，尿液中的放射性回收率分别达到36.4%和22.6%。
