结核性脑膜炎患者脑脊液中的循环免疫复合物。
Circulating immune complexes in cerebrospinal fluid of patients with tuberculous meningitis.
作者信息
Mathai A, Radhakrishnan V V, Sehgal S
机构信息
Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
出版信息
Indian J Exp Biol. 1991 Oct;29(10):973-6.
Circulating immune complexes (ICs) were isolated from cerebrospinal fluids (CSFs) of patients with tuberculous meningitis (TBM), non-tuberculous neurological diseases by a polyethylene glycol (PEG) precipitation method. Mycobacterium tuberculosis antigen 5 was detected in CICs of 30% patients with TBM, by sandwich ELISA. CIC level decreases during antituberculosis chemotherapy and therefore its detection can provide a method to monitor the therapeutic schedule in patients with TBM.
采用聚乙二醇（PEG）沉淀法从结核性脑膜炎（TBM）患者及非结核性神经系统疾病患者的脑脊液（CSF）中分离循环免疫复合物（ICs）。通过夹心ELISA法在30%的TBM患者的循环免疫复合物中检测到结核分枝杆菌抗原5。循环免疫复合物水平在抗结核化疗期间下降，因此其检测可为监测TBM患者的治疗进程提供一种方法。
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