Deshpande D V, Nachne D, Koyande D, Rodriques C J
TNM College and BYL Nair Ch Hospital, Bombay.
J Assoc Physicians India. 1991 Aug;39(8):599-601.
Sixty seven patients with coexistent tuberculosis and hepatitis were given a 3 drug regimen of streptomycin (SM), isonicotinic acid hydrazide (INH) and ethambutol (ETB) and observed for a period of 15 days. Total bilirubin as well as SGPT were repeated weekly and these showed a significant drop in a majority of patients when observed over this period. No patient developed any signs of fulminant hepatic failure. We conclude that a regimen of SM, INH and ETB can be given to patients who suffer from combined pathologies of pulmonary tuberculosis and active hepatitis without incurring the danger of increasing hepatocellular dysfunction/damage.
67例合并肺结核和肝炎的患者接受了链霉素（SM）、异烟肼（INH）和乙胺丁醇（ETB）的三联药物治疗方案，并观察了15天。每周重复检测总胆红素和谷丙转氨酶（SGPT），在此期间观察发现，大多数患者的这些指标显著下降。没有患者出现暴发性肝衰竭的任何迹象。我们得出结论，对于患有肺结核和活动性肝炎合并病症的患者，可以给予SM、INH和ETB的治疗方案，而不会增加肝细胞功能障碍/损伤的风险。
