在中性粒细胞减少小鼠模型中评估载抗体脂质体两性霉素B治疗系统性念珠菌病的效果。

Evaluation of antibody-bearing liposomal amphotericin B in the treatment of systemic candidiasis in a neutropenic murine model.

作者信息

Belay T, Hospenthal D R, Rogers A L, Patterson M J

机构信息

Department of Botany and Plant Pathology, Michigan State University, East Lansing 48824.

出版信息

J Med Vet Mycol. 1991;29(6):419-21. doi: 10.1080/02681219180000671.

DOI:10.1080/02681219180000671

PMID:1815035

Abstract

The efficacy of liposomal amphotericin B bearing anticandidal antibodies (LAMB-Ab) was investigated in the treatment of systemic candidiasis in a murine model made neutropenic by an intraperitoneal injection of cyclophosphamide. Treatment with a single dose (0.6 mg amphotericin B kg-1 body weight) of LAMB-Ab resulted in an improved survival of neutropenic mice infected with Candida albicans compared to neutropenic mice treated with identical doses of liposomal amphotericin B or free amphotericin B.

摘要

在通过腹腔注射环磷酰胺使小鼠中性粒细胞减少而建立的小鼠系统性念珠菌病模型中，研究了携带抗念珠菌抗体的脂质体两性霉素B（LAMB-Ab）的疗效。与用相同剂量的脂质体两性霉素B或游离两性霉素B治疗的中性粒细胞减少小鼠相比，单剂量（0.6mg两性霉素B/kg体重）的LAMB-Ab治疗可提高感染白色念珠菌的中性粒细胞减少小鼠的存活率。