Chueh J, Golbus M S
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
J Perinat Med. 1991;19(6):411-20. doi: 10.1515/jpme.1991.19.6.411.
Currently, all methods of prenatal diagnosis require an invasive approach. The next step in the continuing challenge to make prenatal diagnosis more accessible is the development of a noninvasive test. The presence of fetal cells in the maternal circulation has been debated for several decades, but traditional attempts to identify the rare fetal cell within the pool of maternal cells have met with partial success at best. Today, with the aid of highly sensitive and specific techniques such as fluorescent activated cell sorting, polymerase chain reaction, and in-situ hybridization, the task of finding the "on-in-a-million" fetal cell is moving from the realm of the imagination into that of reality.
目前，所有产前诊断方法都需要采用侵入性手段。在使产前诊断更易获得这一持续挑战中的下一步是开发一种非侵入性检测方法。母血循环中胎儿细胞的存在已被争论了几十年，但传统上试图在母细胞池中识别罕见胎儿细胞的尝试充其量只取得了部分成功。如今，借助荧光激活细胞分选、聚合酶链反应和原位杂交等高灵敏度和特异性技术，寻找“百万分之一”胎儿细胞的任务正从想象领域变为现实。
