穹窿下器化学刺激对大鼠下丘脑-神经垂体系统代谢活性的影响

Effects of chemical stimulation of the subfornical organ on metabolic activity of the hypothalamo-neurohypophysial system in rats.

作者信息

Terrell M L, Kadekaro M, Freeman S, Eisenberg H

机构信息

Division of Neurosurgery, University of Texas Medical Branch, Galveston 77550.

出版信息

Neurosci Lett. 1991 Dec 16;134(1):122-6. doi: 10.1016/0304-3940(91)90522-u.

DOI:10.1016/0304-3940(91)90522-u

PMID:1815144

Abstract

Topical stimulation of the subfornical organ (SFO) with angiotensin II (ANG II) or acetylcholine (ACh) increased blood pressure, water intake, and the activity of the hypothalamo-neurohypophysial system (HNS). The pressor and drinking responses were higher and the metabolic activity of the HNS, measured with the [14C]deoxyglucose (DG) method, was lower with ANG-II than with ACh. Glucose utilization in the neural lobe increased by 165% with ACh as opposed to 65% with ANG II. These results demonstrate the ANG II and ACh mobilize differentially the mechanisms increasing blood pressure, drinking responses, and the activity of the HNS.

摘要

用血管紧张素 II（ANG II）或乙酰胆碱（ACh）对穹窿下器官（SFO）进行局部刺激会升高血压、增加水摄入量，并增强下丘脑 - 神经垂体系统（HNS）的活性。与 ACh 相比，ANG-II 引起的升压和饮水反应更强，而用 [14C]脱氧葡萄糖（DG）法测得的 HNS 的代谢活性更低。与 ANG II 使神经叶中的葡萄糖利用率增加 65% 相比，ACh 可使其增加 165%。这些结果表明，ANG II 和 ACh 以不同方式调动增加血压、饮水反应和 HNS 活性的机制。