丹麦艾滋病或艾滋病相关综合征患者血清和脑脊液乳胶凝集试验检测隐球菌抗原的筛查阳性率低。
Low yield of screening for cryptococcal antigen by latex agglutination assay on serum and cerebrospinal fluid from Danish patients with AIDS or ARC.
作者信息
Hoffmann S, Stenderup J, Mathiesen L R
机构信息
Department of Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Denmark.
出版信息
Scand J Infect Dis. 1991;23(6):697-702. doi: 10.3109/00365549109024296.
From July 1, 1989 to September 5, 1990, 530 serum specimens and 50 cerebrospinal fluid (CSF) specimens from 334 HIV-1 infected patients, most of whom had AIDS or ARC, were analysed in a cryptococcal antigen latex agglutination assay, and all were negative. Three cases of meningitis due to Cryptococcus neoformans diagnosed by microscopy and culture in 3 HIV-1 infected patients are presented. Stored specimens of serum and CSF from these patients were assayed for cryptococcal antigen, and in all 3 the onset of meningitis was preceded by the presence of cryptococcal antigen in serum. It is concluded that the low occurrence of cryptococcosis in our patient population does not justify a routine serum screening for cryptococcal antigen.
1989年7月1日至1990年9月5日，对334例HIV-1感染患者（其中大多数患有艾滋病或艾滋病相关综合征）的530份血清标本和50份脑脊液（CSF）标本进行了隐球菌抗原乳胶凝集试验分析，结果均为阴性。本文报告了3例HIV-1感染患者经显微镜检查和培养确诊为新型隐球菌性脑膜炎的病例。对这些患者储存的血清和脑脊液标本进行了隐球菌抗原检测，在所有3例患者中，脑膜炎发作之前血清中均存在隐球菌抗原。得出的结论是，在我们的患者群体中隐球菌病发生率较低，因此没有理由对隐球菌抗原进行常规血清筛查。
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