Fyllingen G, Arnesen A R, Rønnevig J
Medical Department, Apothekernes Laboratorium AS, Oslo, Norway.
Scand J Infect Dis. 1991;23(6):755-61. doi: 10.3109/00365549109024304.
In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed 2 or 3 times daily was equally effective in bacterial upper respiratory infections. In a randomized, controlled and single blind clinical trial, 131 patients with otitis media, sinusitis and tonsillitis were treated with phenoxymethylpenicillin. 71 received the daily dose twice a day and 60 patients received the daily dose 3 times a day. The dose was adjusted for diagnoses and age. Clinical cure was the endpoint for treatment success. In the 2-dosage group 78.6% had full effect of the treatment and 86.2% had full effect in the 3-dosage group. There was no statistically significant difference. In conclusion phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in bacterial upper respiratory infection.
关于依从性问题，研究了每日给药2次或3次的苯氧甲基青霉素在细菌性上呼吸道感染中是否具有同等疗效。在一项随机、对照、单盲临床试验中，131例中耳炎、鼻窦炎和扁桃体炎患者接受了苯氧甲基青霉素治疗。71例患者每日给药2次，60例患者每日给药3次。剂量根据诊断结果和年龄进行调整。临床治愈是治疗成功的终点。2次给药组78.6%的患者治疗效果完全达标，3次给药组为86.2%。两者无统计学显著差异。总之，每日给药2次或3次的苯氧甲基青霉素在细菌性上呼吸道感染中似乎具有同等疗效。
