METTIER S R, McBRIDE A, TAT R
Calif Med. 1949 Jul;71(1):21-7.
The effect of the parenteral administration of vitamin B(12) has been observed in eight patients with Addisonian pernicious anemia. Vitamin B(12) in initial doses of 50 micrograms or 25 micrograms induced satisfactory reticulocyte response and a return of erythrocyte count to within normal range in 60 days. In only two of the patients were secondary reticulocyte responses induced on a second injection of vitamin B(12). Concurrently with the hemopoietic response, the bone marrow changed from megaloblastic hyperplasia to normoblastic distribution. The paresthesias associated with combined system disease as well as disturbances in position sense and locomotor function may be entirely relieved or greatly diminished following injections of vitamin B(12). Maintenance injections of vitamin B(12) may be from 30 to 50 micrograms at intervals of one month, the amount depending upon the individual case. Vitamin B(12) may be used without untoward symptoms in patients previously sensitive to liver extract.
已对8例艾迪生病性恶性贫血患者观察了胃肠外给予维生素B12的效果。初始剂量为50微克或25微克的维生素B12可诱导出令人满意的网织红细胞反应，并使红细胞计数在60天内恢复到正常范围。仅2例患者在第二次注射维生素B12时诱导出继发性网织红细胞反应。在造血反应的同时，骨髓从巨幼细胞增生转变为正常幼红细胞分布。注射维生素B12后，与联合系统疾病相关的感觉异常以及位置觉和运动功能障碍可能会完全缓解或大大减轻。维生素B12的维持注射剂量可为30至50微克，间隔1个月，剂量根据个体情况而定。以前对肝提取物敏感的患者使用维生素B12可能不会出现不良反应。
