孔雀鱼（Poecilia reticulata）体内芳香胺的毒代动力学

Toxicokinetics of aromatic amines in guppy, Poecilia reticulata.

作者信息

de Wolf W, Yedema E, Seinen W, Hermens J L

机构信息

Research Institute of Toxicology, University of Utrecht, Netherlands.

出版信息

Sci Total Environ. 1991 Dec;109-110:383-6. doi: 10.1016/0048-9697(91)90192-h.

DOI:10.1016/0048-9697(91)90192-h

PMID:1815358

Abstract

In this study the elimination kinetics of several chlorinated anilines and a tetrachlorobenzene in guppy, Poecilia reticulata, have been determined. The elimination of all the chlorinated anilines in fish showed a bi-phasic pattern, whereas the elimination characteristics of the tetrachlorobenzene are in agreement with a one-compartment model. Elimination of the chlorinated anilines is faster than elimination of the tetrachlorobenzene. The small differences in octanol-water partition coefficient of these compounds can only in part describe the differences in elimination rate. The observed differences might be attributed to differing biotransformation rates.

摘要

在本研究中，已测定了孔雀鱼（Poecilia reticulata）体内几种氯代苯胺和一种四氯苯的消除动力学。鱼类体内所有氯代苯胺的消除呈现双相模式，而四氯苯的消除特征符合一室模型。氯代苯胺的消除速度比四氯苯快。这些化合物在辛醇 - 水分配系数上的微小差异只能部分解释消除速率的差异。观察到的差异可能归因于不同的生物转化速率。