Bershteĭn L M, Kovalevskiĭ A Iu, Poroshina T E, Kovalenko I G, Kotov A V, Semenov I I, Pozharisskiĭ K M
Vopr Onkol. 2007;53(5):515-20.
Breast cancer course may be influenced by a profile of steroids and peptides produced by mammary fat. The study was concerned with assessment of hormonal (leptin and adiponectin production, adipocyte diameter and aromatase level) and progenotoxic factors which characterize DNA damage (8-OHdG) and such cancer promoters as tumor necrosis (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO), thiobarbiturate reactive products (TRP), macrophage/histiocyte infiltration, estrogen 4-hydroxylase expression (CYP1B1) in mammary fat located 1.5-2 cm or not less than 5 cm away from tumor edge. Thirty-three pairs of mammary fat samples from 23 menopausal and 10 cycling patients were used. Closer proximity of mammary fat involved intensified biosynthesis of estrogens (as shown by aromatase level) and their conversion to catechol derivatives (as shown by CYP1B1 concentration) as well as accumulation of 8-OH-dG. Smoking and hyperglycemic patients and those with considerable mammary fat volume revealed accumulations of anti-inflammatory and progenotoxic cytokines (IL-6 or TNF-alpha). Hence, hormonal/progenotoxic ratio in mammary fat can be identified both by topographic, systemic and environmental factors.
乳腺癌的病程可能会受到乳腺脂肪产生的一系列类固醇和肽的影响。该研究关注的是对激素（瘦素和脂联素的产生、脂肪细胞直径和芳香化酶水平）以及遗传毒性因子的评估，这些因子可表征DNA损伤（8-羟基脱氧鸟苷）以及诸如肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、一氧化氮（NO）、硫代巴比妥酸反应产物（TRP）等癌症促进因子，还有距肿瘤边缘1.5 - 2厘米或不少于5厘米处乳腺脂肪中的巨噬细胞/组织细胞浸润以及雌激素4-羟化酶表达（CYP1B1）情况。研究使用了来自23名绝经患者和10名育龄患者的33对乳腺脂肪样本。靠近肿瘤的乳腺脂肪会增强雌激素的生物合成（如芳香化酶水平所示）及其向儿茶酚衍生物的转化（如CYP1B1浓度所示）以及8-羟基脱氧鸟苷的积累。吸烟、血糖高的患者以及乳腺脂肪量较多的患者体内会出现抗炎和遗传毒性细胞因子（IL-6或TNF-α）的积累。因此，乳腺脂肪中的激素/遗传毒性比值可通过地形、全身和环境因素来确定。
