伊朗2型糖尿病患者血管紧张素转换酶基因插入/缺失多态性与代谢综合征的关联

Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in Iranians with type 2 diabetes mellitus.

作者信息

Nikzamir Abdolrahim, Nakhjavani Manouchehr, Golmohamadi Taghi, Dibai Ladan

机构信息

Endocrinology and Metabolism Research Center (EMRC), Vali-e-Asr Hospital, Tehran, Iran. Nikzamirar @yahoo.com

出版信息

Arch Iran Med. 2008 Jan;11(1):3-9.

PMID:18154415

Abstract

BACKGROUND

Angiotensin-converting enzyme insertion/deletion polymorphism has been shown to be associated with diabetes, hypertension, coronary artery diseases, and diabetic nephropathy. The objective of this study was to investigate whether angiotensin-converting enzyme gene insertion/deletion polymorphism is associated with metabolic syndrome in Iranians with type 2 diabetes mellitus.

METHODS

A total of 170 patients with type 2 diabetes mellitus and 91 control subjects were studied. The angiotensin-converting enzyme insertion/deletion polymorphism was determined by polymerase chain reaction (PCR) utilizing specific primers. The definition and criteria of metabolic syndrome used in this study matched that proposed in 1998 World Health Organization classification.

RESULTS

Of 170 patients studied, 119 (70%) fulfilled the criteria for metabolic syndrome. The prevalence of angiotensin-converting enzyme genotype in the control subjects with DD, ID, and II genotype was 13.2%, 47.3%, and 39.5%, respectively. In patients with metabolic syndrome, the prevalence was 26.9%, 56.3%, and 16.8%, respectively; in patients without metabolic syndrome, it was 21.6%, 62.7%, and 15.7%, respectively. The angiotensin-converting enzyme insertion/deletion polymorphism was not significantly associated with presence of metabolic syndrome in patients with type 2 diabetes (P=0.711). The frequency of DD genotype in the metabolic syndrome group (26.9%) was higher than that (21.6%) in those without metabolic syndrome (P=0.447) and the control group (13.2%, P=0.02). The frequency of D allele in metabolic syndrome patients was 55.1% as compared to those patients without metabolic syndrome (52.9%, P=0.72) and the control subjects (36.8%, P<0.001).

CONCLUSION

It seems that the DD genotype and/or D allele of angiotensin-converting enzyme gene may increase the risk for developing type 2 diabetes mellitus, but not metabolic syndrome.

摘要

背景

血管紧张素转换酶插入/缺失多态性已被证明与糖尿病、高血压、冠状动脉疾病和糖尿病肾病有关。本研究的目的是调查血管紧张素转换酶基因插入/缺失多态性是否与伊朗2型糖尿病患者的代谢综合征有关。

方法

共研究了170例2型糖尿病患者和91例对照者。利用特异性引物通过聚合酶链反应（PCR）确定血管紧张素转换酶插入/缺失多态性。本研究中使用的代谢综合征的定义和标准与1998年世界卫生组织分类中提出的一致。

结果

在研究的170例患者中，119例（70%）符合代谢综合征标准。对照者中DD、ID和II基因型的血管紧张素转换酶基因型患病率分别为13.2%、47.3%和39.5%。在代谢综合征患者中，患病率分别为26.9%、56.3%和16.8%；在无代谢综合征的患者中，分别为21.6%、62.7%和15.7%。血管紧张素转换酶插入/缺失多态性与2型糖尿病患者代谢综合征的存在无显著相关性（P = 0.711）。代谢综合征组中DD基因型的频率（26.9%）高于无代谢综合征组（21.6%，P = 0.447）和对照组（13.2%，P = 0.02）。代谢综合征患者中D等位基因的频率为55.1%，而无代谢综合征患者为52.9%（P = 0.72），对照者为36.8%（P < 0.001）。