神经型布鲁氏菌病的临床与实验室检查结果：31例病例回顾
Clinical and laboratory findings in neurobrucellosis: review of 31 cases.
作者信息
Haji-Abdolbagi Mahboubeh, Rasooli-Nejad Mehrnaz, Jafari Sirous, Hasibi Mehrdad, Soudbakhsh Abdolreza
机构信息
Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Arch Iran Med. 2008 Jan;11(1):21-5.
BACKGROUND
Neurobrucellosis is an uncommon complication of brucellosis. The clinical features of neurobrucellosis vary greatly and, in general, tend to be chronic. Many of the laboratory procedures usually employed in the diagnosis of brucellosis frequently give negative results. For these reasons, and because brucellosis is a disease, which is both treatable and curable, the degree of suspicion must be high, especially in endemic areas, so that an early diagnosis can be made to allow suitable treatment to be established.
METHODS
A retrospective analysis of 31 cases of neurobrucellosis was carried out.
RESULTS
Meningitis and meningoencephalitis were the most common form of neurobrucellosis in our patients. The most commonly-used antibiotics were combinations of rifampin, doxycycline, and trimethoprim-sulfamethoxazole.
CONCLUSION
The differential diagnosis of neurobrucellosis is wide. However, the disease should be ruled out in all patients who develop unexplained neurological symptoms, especially in those who live in endemic areas.
背景
神经型布鲁氏菌病是布鲁氏菌病的一种罕见并发症。神经型布鲁氏菌病的临床特征差异很大，总体上倾向于慢性。许多通常用于诊断布鲁氏菌病的实验室检查常常得出阴性结果。由于这些原因，并且因为布鲁氏菌病是一种可治疗且可治愈的疾病，所以怀疑程度必须很高，尤其是在流行地区，以便能够早期诊断并确立适当的治疗方法。
方法
对31例神经型布鲁氏菌病病例进行回顾性分析。
结果
脑膜炎和脑膜脑炎是我们患者中神经型布鲁氏菌病最常见的形式。最常用的抗生素是利福平、多西环素和甲氧苄啶 - 磺胺甲恶唑的联合用药。
结论
神经型布鲁氏菌病的鉴别诊断范围很广。然而，对于所有出现不明原因神经症状的患者，尤其是居住在流行地区的患者，都应排除该病。
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