Ye J, Kraegen T
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Obes Rev. 2008 Jan;9(1):30-4. doi: 10.1111/j.1467-789X.2007.00402.x.
Insulin resistance in peripheral tissues and in the brain are fundamental to the development of obesity and its associated type 2 diabetes. Multiple mechanisms contribute to the development of insulin resistance. The 2007 Stock Conference focused on the role of fatty acids and other lipid signals in initiating insulin resistance and the consequences of central insulin resistance to the regulation of energy balance and peripheral metabolism.
