特殊调节性T细胞综述：我如何成为一名T抑制/调节细胞专家。
Special regulatory T cell review: How I became a T suppressor/regulatory cell maven.
作者信息
Shevach Ethan M
机构信息
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunology. 2008 Jan;123(1):3-5. doi: 10.1111/j.1365-2567.2007.02777.x.
Abstract
I have briefly reviewed the factors that motivated me to change my views about the existence and importance of suppressor/regulatory T cells and to devote the majority of my laboratory efforts to this newly revitalized area of immunologic research. I am optimistic that manipulation of regulatory T-cell function will shortly be applicable to the clinic.
摘要
我简要回顾了一些因素，这些因素促使我改变了对抑制性/调节性T细胞的存在及其重要性的看法，并将我实验室的大部分精力投入到这个重新焕发生机的免疫研究领域。我乐观地认为，调节性T细胞功能的操控不久将应用于临床。
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本文引用的文献
1
Certified professionals: CD4(+)CD25(+) suppressor T cells.认证专业人员：CD4(+)CD25(+)抑制性T细胞。
J Exp Med. 2001 Jun 4;193(11):F41-6. doi: 10.1084/jem.193.11.f41.
2
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.胸腺切除术后自身免疫性胃炎：抗H/K ATP酶反应性T细胞的精细特异性和致病性
Eur J Immunol. 1999 Feb;29(2):669-77. doi: 10.1002/(SICI)1521-4141(199902)29:02<669::AID-IMMU669>3.0.CO;2-J.
3
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.CD4+CD25+免疫调节性T细胞通过抑制白细胞介素2的产生在体外抑制多克隆T细胞活化。
J Exp Med. 1998 Jul 20;188(2):287-96. doi: 10.1084/jem.188.2.287.
4
5
Post-thymectomy autoimmunity: abnormal T-cell homeostasis.胸腺切除术后自身免疫：异常的T细胞稳态。
Immunol Today. 1995 Feb;16(2):61-7. doi: 10.1016/0167-5699(95)80089-1.
6
7
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.一种与小鼠白细胞介素2受体-配体复合物反应的大鼠单克隆抗体的鉴定及初步表征。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8. doi: 10.1073/pnas.80.18.5694.
8
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.编码T细胞特异性膜相关蛋白的cDNA克隆的分离
Nature. 1984;308(5955):149-53. doi: 10.1038/308149a0.
9
RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.I-J多肽的RNA转录本显然不是由小鼠主要组织相容性复合体的I-A和I-E亚区之间编码的。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5704-8. doi: 10.1073/pnas.80.18.5704.
10
Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice.胸腺与生殖：小鼠新生期胸腺切除术后性腺的性连锁发育异常
Science. 1969 Nov 7;166(3906):753-5. doi: 10.1126/science.166.3906.753.
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