特殊调节性T细胞综述：我如何成为一名T抑制/调节细胞专家。
Special regulatory T cell review: How I became a T suppressor/regulatory cell maven.
作者信息
Shevach Ethan M
机构信息
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunology. 2008 Jan;123(1):3-5. doi: 10.1111/j.1365-2567.2007.02777.x.
Abstract
I have briefly reviewed the factors that motivated me to change my views about the existence and importance of suppressor/regulatory T cells and to devote the majority of my laboratory efforts to this newly revitalized area of immunologic research. I am optimistic that manipulation of regulatory T-cell function will shortly be applicable to the clinic.
摘要
我简要回顾了一些因素，这些因素促使我改变了对抑制性/调节性T细胞的存在及其重要性的看法，并将我实验室的大部分精力投入到这个重新焕发生机的免疫研究领域。我乐观地认为，调节性T细胞功能的操控不久将应用于临床。
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本文引用的文献
1
Certified professionals: CD4(+)CD25(+) suppressor T cells.
J Exp Med. 2001 Jun 4;193(11):F41-6. doi: 10.1084/jem.193.11.f41.
2
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.
Eur J Immunol. 1999 Feb;29(2):669-77. doi: 10.1002/(SICI)1521-4141(199902)29:02<669::AID-IMMU669>3.0.CO;2-J.
3
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
J Exp Med. 1998 Jul 20;188(2):287-96. doi: 10.1084/jem.188.2.287.
4
5
Post-thymectomy autoimmunity: abnormal T-cell homeostasis.
Immunol Today. 1995 Feb;16(2):61-7. doi: 10.1016/0167-5699(95)80089-1.
6
7
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8. doi: 10.1073/pnas.80.18.5694.
8
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.
Nature. 1984;308(5955):149-53. doi: 10.1038/308149a0.
9
RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5704-8. doi: 10.1073/pnas.80.18.5704.
10
Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice.
Science. 1969 Nov 7;166(3906):753-5. doi: 10.1126/science.166.3906.753.
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