Matran R, Alving K, Lundberg J M
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Acta Physiol Scand. 1991 Dec;143(4):387-93. doi: 10.1111/j.1748-1716.1991.tb09250.x.
The pulmonary and bronchial vascular responses and changes in bronchial tone upon vagal stimulation (240 impulses at 2 Hz or 10 Hz) were studied in anaesthetized pigs paralyzed with pancuronium. The acetylcholine-evoked vasodilatation in the tracheobronchial circulation had the same magnitude when using pancuronium or succinylcholine as skeletal muscle relaxants. Atropine-sensitive bradycardia, hypotension and bronchoconstriction were observed upon vagal stimulation. A vasoconstrictor response in the pulmonary vascular bed and clear-cut vasodilatation in the bronchial circulation supplied by the bronchial artery also occurred upon vagal stimulation. The vagally-evoked increase in pulmonary vascular resistance was markedly reduced after atropine while the bronchial vasodilatation was unchanged. This suggests that the vagally-induced increase in bronchial blood flow was not secondary to changes in the pulmonary circulation. Furthermore, the pulmonary vasoconstrictor response caused by vagal stimulation under control conditions is probably explained by reflex sympathetic activation due to the fall in systemic blood pressure. These data indicate selective vagal non-cholinergic influence of blood flow in the bronchial vascular bed compared to the pulmonary circulation.
在使用泮库溴铵麻痹的麻醉猪中，研究了迷走神经刺激（2赫兹或10赫兹下240次冲动）时的肺和支气管血管反应以及支气管张力变化。当使用泮库溴铵或琥珀酰胆碱作为骨骼肌松弛剂时，乙酰胆碱诱发的气管支气管循环中的血管舒张幅度相同。迷走神经刺激时观察到对阿托品敏感的心动过缓、低血压和支气管收缩。迷走神经刺激时，肺血管床也出现血管收缩反应，支气管动脉供应的支气管循环中出现明显的血管舒张。阿托品给药后，迷走神经诱发的肺血管阻力增加明显降低，而支气管血管舒张无变化。这表明迷走神经诱发的支气管血流增加并非继发于肺循环的变化。此外，对照条件下迷走神经刺激引起的肺血管收缩反应可能是由于全身血压下降导致的反射性交感神经激活所致。这些数据表明，与肺循环相比，迷走神经对支气管血管床血流具有选择性的非胆碱能影响。
