糖皮质激素受体（DlGR1）在硬骨鱼欧洲鲈的多个组织中的表达。
Expression of a glucocorticoid receptor (DlGR1) in several tissues of the teleost fish Dicentrarchus labrax.
作者信息
Vazzana M, Vizzini A, Salerno G, Di Bella M L, Celi M, Parrinello N
机构信息
Laboratory of Marine Immunobiology, Department of Animal Biology, University of Palermo, Via Archirafi 18, Palermo, Italy.
出版信息
Tissue Cell. 2008 Apr;40(2):89-94. doi: 10.1016/j.tice.2007.09.008. Epub 2007 Dec 21.
Since glucocorticoids have a role in maintaining the homeostatic status in fish, in the present paper mRNA expression (in situ hybridization) and tissue immunohistochemical localization of a glucocorticoid receptor (DlGR1) in several Dicentrarchus labrax organs are reported. Riboprobe and specific antibodies were prepared by using the DlGR1 that has been previously cloned and sequenced from peritoneal cavity leukocytes. Both mRNA and receptor were identified in head kidney, spleen, gills, intestine, heart and liver tissues. The functional roles of DlGR1 localization are discussed.
由于糖皮质激素在维持鱼类体内稳态中发挥作用，本文报道了糖皮质激素受体（DlGR1）在几条欧洲鲈鱼器官中的mRNA表达（原位杂交）和组织免疫组化定位。利用先前从腹腔白细胞中克隆和测序的DlGR1制备了核糖探针和特异性抗体。在头肾、脾脏、鳃、肠、心脏和肝脏组织中均鉴定出了mRNA和受体。并讨论了DlGR1定位的功能作用。
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