Proulx Christophe D, Holleran Brian J, Lavigne Pierre, Escher Emanuel, Guillemette Gaétan, Leduc Richard
Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, J1H 5N4 Canada.
Peptides. 2008 May;29(5):691-9. doi: 10.1016/j.peptides.2007.10.027. Epub 2007 Nov 17.
The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT.
尾加压素II受体（UT）是G蛋白偶联受体（GPCR）家族的成员，可结合环十一肽尾加压素II（U-II）以及八肽尾加压素II相关肽（URP）。活性UT通过多种信号转导途径介导多效性作用，包括与G蛋白偶联并激活丝裂原活化蛋白激酶途径。在UT中发现了A类GPCR的几个对活性很重要的高度保守的残基和基序。本文综述重点介绍了这些基序在UT的结合、激活和脱敏中的一些假定作用。
