Markarian S A, Grigoryan J D, Sargsyan H R
Department of Chemistry, Yerevan State University, Yerevan, Armenia.
Int J Pharm. 2008 Apr 2;353(1-2):52-5. doi: 10.1016/j.ijpharm.2007.11.019. Epub 2007 Nov 17.
The effect of dimethyl sulfoxide (DMSO) and its nearest homologue diethyl sulfoxide (DESO) as a polar cosolvents on the binding of vitamin E to water + DMSO (DESO) containing reversed micelles of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) has been investigated by a spectrophotometric method. The results suggest that compare with water without organic cosolvent-containing reversed micelles in this case an increase of binding constant of vitamin E in reversed micelles takes place. The results obtained shown that with the addition of DMSO and DESO it will be possible to monitoring a penetration of vitamin E into micellar core.
已通过分光光度法研究了二甲基亚砜（DMSO）及其最接近的同系物二乙基亚砜（DESO）作为极性助溶剂对维生素E与含有双（2-乙基己基）磺基琥珀酸钠（AOT）反相胶束的水+ DMSO（DESO）结合的影响。结果表明，与在这种情况下不含有机助溶剂的反相胶束的水相比，反相胶束中维生素E的结合常数增加。所得结果表明，添加DMSO和DESO后，将有可能监测维生素E向胶束核心的渗透。
