针对L1细胞粘附分子（L1-CAM）的抗体与染料木黄酮协同作用，抑制SKOV3ip人卵巢癌细胞的生长和生存途径。
Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells.
作者信息
Novak-Hofer Ilse, Cohrs Susan, Grünberg Jürgen, Friedli Alexandra, Schlatter Monika C, Pfeifer Marco, Altevogt Peter, Schubiger P August
机构信息
Center for Radiopharmaceutical Science ETH-PSI-USZ, Paul Scherrer Institute, Villigen, Switzerland.
出版信息
Cancer Lett. 2008 Mar 18;261(2):193-204. doi: 10.1016/j.canlet.2007.11.012. Epub 2007 Dec 26.
Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.
针对L1细胞粘附蛋白的抗体在体外和体内均可抑制SKOV3ip人卵巢癌细胞的生长。研究了SKOV3ip细胞在体外对抗L1单克隆抗体chCE7和染料木黄酮的反应。染料木黄酮增强了chCE7对SKOV3ip细胞的抗增殖和促凋亡作用。单克隆抗体chCE7与染料木黄酮联合使用可显著降低p44/42（Erk1,2）激酶、Src激酶和Akt激酶对血清、表皮生长因子和肝细胞生长因子细胞外刺激的敏感性。观察到的针对L1的抗体与染料木黄酮的协同作用可能为卵巢癌带来新的治疗选择。
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