Korinth Gintautas, Lüersen Lars, Schaller Karl Heinz, Angerer Jürgen, Drexler Hans
Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen-Nuremberg, Schillerstrasse 25/29, D-91054 Erlangen, Germany.
Toxicol In Vitro. 2008 Apr;22(3):812-8. doi: 10.1016/j.tiv.2007.11.006. Epub 2007 Nov 12.
Aniline (ANI) and the human carcinogen o-toluidine (OT) are released at the workplace during the production and processing of rubber. Recently, we showed in rubber industry workers that a frequent use of skin barrier creams (SBC) increased the internal exposure of ANI and OT. In the present study, diffusion cells were used to investigate the effects of two SBC and one skin care cream (SCC) on percutaneous penetration of neat ANI and OT as well as of OT from a mixture with a workplace specific lubricant. The experiments were carried out with untreated and with skin creams treated human skin. A considerable percutaneous penetration enhancement of test compounds was observed for treated skin compared with untreated skin; the highest enhancement (mean factors 6.2-12.3) was found for SBC (based on oil in water emulsion) treated skin. The lowest penetration enhancement showed SCC treated skin (mean factors 4.2-9.7). The in vitro data support our findings in workers that the percutaneous absorption of aromatic amines significantly increases in presence of skin creams. The efficacy of skin creams to protect the percutaneous penetration of aromatic amines is not confirmed by our own experiments.
在橡胶生产和加工过程中， workplace会释放苯胺（ANI）和人类致癌物邻甲苯胺（OT）。最近，我们在橡胶行业工人中发现，频繁使用皮肤屏障霜（SBC）会增加ANI和OT的体内暴露量。在本研究中，使用扩散池研究了两种SBC和一种护肤品（SCC）对纯ANI和OT以及与工作场所特定润滑剂混合的OT经皮渗透的影响。实验在未处理的皮肤和使用护肤霜处理过的人皮肤上进行。与未处理的皮肤相比，经处理的皮肤对测试化合物的经皮渗透有显著增强；对于经SBC（基于水包油乳液）处理的皮肤，增强效果最高（平均系数为6.2-12.3）。经SCC处理的皮肤的渗透增强效果最低（平均系数为4.2-9.7）。体外数据支持了我们在工人中的发现，即存在护肤霜时芳香胺的经皮吸收会显著增加。我们自己的实验未证实护肤霜对保护芳香胺经皮渗透的功效。
