Levin M J, Franco da Silveira J, Frasch A C, Camargo M E, Lafon S, Degrave W M, Rangel-Aldao R
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Buenos Aires, Argentina.
FEMS Microbiol Immunol. 1991 Dec;4(1):11-9. doi: 10.1111/j.1574-6968.1991.tb04965.x.
A workshop organized by the Ibero-American Project of Biotechnology evaluated the diagnostic potential of several cloned Trypanosoma cruzi recombinant antigens for Chagas' disease serodiagnosis. A set of recombinants, Antigen 2, Antigen 13, SAPA, H49, A13, JL5, JL7, JL8, JL9, and RA1 provided by three different South American laboratories were probed with a panel of 236 South American serum samples. Antigens JL7, H49, Antigen 2, and A13 scored as the best diagnostic recombinant reagents. The results suggested that the main advantage of using cloned peptides for chronic Chagas' disease diagnosis resided in their highly specific immunoreactive properties.
由伊比利亚美洲生物技术项目组织的一次研讨会评估了几种克隆的克氏锥虫重组抗原用于恰加斯病血清学诊断的潜力。来自三个不同南美实验室提供的一组重组体，即抗原2、抗原13、SAPA、H49、A13、JL5、JL7、JL8、JL9和RA1，用一组236份南美血清样本进行了检测。抗原JL7、H49、抗原2和A13被评为最佳诊断重组试剂。结果表明，使用克隆肽诊断慢性恰加斯病的主要优势在于其高度特异性的免疫反应特性。
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