Park Wan Beom, Jang Hee-Chang, Kim Sung-Han, Kim Hong Bin, Kim Nam Joong, Oh Myoung-Don, Choe Kang Won
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Sex Transm Dis. 2008 Mar;35(3):304-6. doi: 10.1097/OLQ.0b013e31815b0148.
To evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients.
Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (primary or secondary) syphilis. Incidence rate trends according to time from HAART initiation were evaluated by Poisson regression after adjustment for calendar year.
With median follow-up of 2.9 years, 56 (10.4%) patients experienced early syphilis, 17 (3.2%) with primary syphilis, and 39 (7.2%) with secondary syphilis. The overall incidence rate of early syphilis for 4 years after the start of HAART was 4.57 per 100 person-years (95% confidence interval, 3.45-5.93). The incidence rate of early syphilis significantly increased in proportion to the years after the start of HAART (3.4-6.1 per 100 person-year, P for trend <0.001).
Early syphilis incidence in HIV-infected patients increased in proportion to HAART duration. The finding suggests that screening for syphilis in HIV-infected patients who initiate HAART should be encouraged with attention to the time passed since HAART initiation.
基于高效抗逆转录病毒治疗（HAART）开始时间，评估人类免疫缺陷病毒（HIV）感染患者中早期梅毒的发病率。
对539例接受HAART的HIV阳性患者进行了长达4年的随访，以确定早期（一期或二期）梅毒。在对日历年进行调整后，通过泊松回归评估根据HAART开始时间的发病率趋势。
中位随访时间为2.9年，56例（10.4%）患者发生早期梅毒，17例（3.2%）为一期梅毒，39例（7.2%）为二期梅毒。HAART开始后4年早期梅毒的总体发病率为每100人年4.57例（95%置信区间，3.45 - 5.93）。早期梅毒的发病率与HAART开始后的年份成比例显著增加（每100人年3.4 - 6.1例，趋势P<0.001）。
HIV感染患者中早期梅毒的发病率与HAART持续时间成比例增加。这一发现表明，对于开始HAART的HIV感染患者，应鼓励进行梅毒筛查，并关注自HAART开始以来经过的时间。
