Zantut-Wittmann Denise E, Garmes Heraldo Mendes, Panzan Anita Denardo, Lima Marcelo de Oliveira, Baptista Maria Tereza Matias
Endocrinology Division, Faculty of Medical Sciences, University of Campinas, Rua Tessália Vieira de Camargo 126, Campinas, SP.
Arq Bras Endocrinol Metabol. 2007 Oct;51(7):1175-9. doi: 10.1590/s0004-27302007000700023.
The association of diabetes insipidus and adipsia after craniopharyngioma surgery has high morbidity. Hypernatremia can be caused by adipsia and be aggravated by diabetes insipidus. Rhabdomyolysis rarely occurs.
This is the first report of a diabetic patient with craniopharyngioma who developed diabetes insipidus and adipsia after surgery, evolving with severe hypernatremia that caused considerable rhabdomyolysis.
The importance of the evaluation of muscle integrity when under hypernatremic states is pointed out. Although adipsia may have a simple solution through volunteer water ingestion, serious consequences such as repeated severe hypernatremia episodes and intense rhabdomyolysis with high morbidity could occur, if adipsia is not diagnosed.
颅咽管瘤手术后尿崩症和渴感缺失的关联具有高发病率。渴感缺失可导致高钠血症，并因尿崩症而加重。横纹肌溶解很少发生。
这是首例颅咽管瘤糖尿病患者术后发生尿崩症和渴感缺失，并进展为严重高钠血症导致明显横纹肌溶解的报告。
指出了高钠血症状态下评估肌肉完整性的重要性。尽管渴感缺失可通过自愿饮水得到简单解决，但如果未诊断出渴感缺失，可能会发生反复严重高钠血症发作和严重横纹肌溶解等高发病率的严重后果。
