Elkis Helio, Meltzer Herbert Y
Departamento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Braz J Psychiatry. 2007 Oct;29 Suppl 2:S41-7. doi: 10.1590/s1516-44462007000600002.
The aim of the present paper is to review the various aspects of refractory schizophrenia regarding issues such as definitions, clinical aspects, psychobiological correlates, pharmacological and non-pharmacological treatment options and predictors of treatment response.
Medline search as well as articles of the authors.
Refractory schizophrenia affects at least one third of patients with schizophrenia and the best evidence shows that is monotherapy with clozapine remains the mainstay for the treatment of such condition. Antipsychotic polipharmacy is not supported by current evidence and recent clinical trials have shown that clozapine augmentation with antipsychotics has no benefit over placebo.
本文旨在综述难治性精神分裂症在定义、临床特征、心理生物学关联、药物及非药物治疗选择以及治疗反应预测因素等方面的各种情况。
检索Medline以及作者的文章。
难治性精神分裂症影响至少三分之一的精神分裂症患者，最佳证据表明，氯氮平单一疗法仍是治疗此类病症的主要方法。目前的证据不支持使用抗精神病药物联合治疗，最近的临床试验表明，抗精神病药物增强氯氮平治疗效果并不优于安慰剂。
