Yang Wen-Wei, Zhou Xiao-Ming, Zhang Ji-Ping, Sun Xin-De
College of Life Sciences, Research Center for Brain Science, East China Normal University, Shanghai 200062, China.
Sheng Li Xue Bao. 2007 Dec 25;59(6):784-90.
Using conventional electrophysiological technique, we investigated the effects of stimulating the medial prefrontal cortex (mPFC) on plasticity of frequency receptive field (RF) in auditory cortical (AC) neurons in rats. When the mPFC was electrically stimulated, the RF plasticity of 51 (27.2%) neurons was not affected and that of 137 neurons (72.8%) was either inhibited (71 neurons, 37.7%) or facilitated (66 neurons, 35.1%). The modulation of RF plasticity by the stimulation of mPFC was dependent upon the time interval between acoustic and electrical stimuli. The best interval time that produced optimal modulation (inhibition or facilitation) ranged from 5 to 30 ms. The inhibitory modulation of mPFC prolonged RF shifting time and shortened RF recovery time. Conversely, the facilitatory modulation of mPFC shortened RF shifting time and prolonged RF recovery time. Our results suggest that the mPFC may affect the plasticity of functional activity in AC neurons, and also may participate in the process of auditory learning and memory.
采用传统电生理技术，我们研究了刺激大鼠内侧前额叶皮质（mPFC）对听皮层（AC）神经元频率感受野（RF）可塑性的影响。当电刺激mPFC时，51个神经元（27.2%）的RF可塑性未受影响，137个神经元（72.8%）的RF可塑性受到抑制（71个神经元，37.7%）或易化（66个神经元，35.1%）。mPFC刺激对RF可塑性的调节取决于声刺激和电刺激之间的时间间隔。产生最佳调节（抑制或易化）的最佳间隔时间为5至30毫秒。mPFC的抑制性调节延长了RF移位时间并缩短了RF恢复时间。相反，mPFC的易化性调节缩短了RF移位时间并延长了RF恢复时间。我们的结果表明，mPFC可能影响AC神经元功能活动的可塑性，也可能参与听觉学习和记忆过程。
