Lidzba K, Wilke M, Staudt M, Krägeloh-Mann I, Grodd W
Department of Developmental Neurology, University Children's Hospital, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany.
Brain Lang. 2008 Sep;106(3):204-10. doi: 10.1016/j.bandl.2007.11.003. Epub 2007 Dec 26.
Patients with congenital lesions of the left cerebral hemisphere may reorganize language functions into the right hemisphere. In these patients, language production is represented homotopically to the left-hemispheric language areas. We studied cerebellar activation in five patients with congenital lesions of the left cerebral hemisphere to assess if the language network is reorganized completely in these patients, i.e. including also cerebellar language functions. As compared to a group of controls matched for age, sex, and verbal IQ, the patients recruited an area not in the right but in the left cerebellar hemisphere. The extent of laterality of the cerebellar activation correlated significantly with the laterality of the frontal activation. We suggest that the developing brain reacts to early focal lesions in the left hemisphere with a mirror-image organization of the entire cerebro-cerebellar network engaged in speech production.
患有先天性左侧大脑半球病变的患者可能会将语言功能重新组织到右侧半球。在这些患者中，语言产生在右侧半球与左侧半球语言区域呈同位代表。我们研究了5例先天性左侧大脑半球病变患者的小脑激活情况，以评估这些患者的语言网络是否完全重新组织，即是否也包括小脑语言功能。与一组年龄、性别和言语智商匹配的对照组相比，这些患者激活的是左侧而非右侧小脑半球的一个区域。小脑激活的偏侧程度与额叶激活的偏侧程度显著相关。我们认为，发育中的大脑对左侧半球早期局灶性病变的反应是，参与言语产生的整个脑-小脑网络呈镜像组织。
