Zhang Pingshu, Duan Liqin, Ou Ya, Ling Qirong, Cao Lingyun, Qian Hongchun, Zhang Jian, Wang Jing, Yuan Xiaodong
Department of Neurology, Kailuan General Hospital, North China University of Technology, Tangshan, Hebei, China.
Key Laboratory of Neurobiological Function in Hebei Province, Tangshan, Hebei, China.
Front Hum Neurosci. 2023 Jul 28;17:1197459. doi: 10.3389/fnhum.2023.1197459. eCollection 2023.
Cognitive function represents a complex neurophysiological capacity of the human brain, encompassing a higher level of neural processing and integration. It is widely acknowledged that the cerebrum plays a commanding role in the regulation of cognitive functions. However, the specific role of the cerebellum in cognitive processes has become a subject of considerable scholarly intrigue. In 1998, Schmahmann first proposed the concept of "cognitive affective syndrome (CCAS)," linking cerebellar damage to cognitive and emotional impairments. Since then, a substantial body of literature has emerged, exploring the role of the cerebellum in cognitive neurological function. The cerebellum's adjacency to the cerebral cortex, brainstem, and spinal cord suggests that the cerebral-cerebellar network loops play a crucial role in the cerebellum's participation in cognitive neurological functions. In this review, we comprehensively examine the recent literature on the involvement of the cerebellum in cognitive functions from three perspectives: the cytological basis of the cerebellum and its anatomical functions, the cerebellum and cognitive functions, and Crossed cerebellar diaschisis. Our aim is to shed light on the role and mechanisms of the cerebellum in cognitive neurobrain networks.
认知功能代表了人类大脑复杂的神经生理能力，涵盖了更高层次的神经处理和整合。人们普遍认为，大脑在认知功能的调节中起着主导作用。然而，小脑在认知过程中的具体作用已成为相当多学术研究的热点。1998年，施马曼首次提出“认知情感综合征（CCAS）”的概念，将小脑损伤与认知和情感障碍联系起来。从那时起，大量文献涌现，探讨小脑在认知神经功能中的作用。小脑与大脑皮层、脑干和脊髓相邻，这表明大脑-小脑网络环路在小脑参与认知神经功能中起着关键作用。在这篇综述中，我们从三个角度全面审视了关于小脑参与认知功能的最新文献：小脑的细胞学基础及其解剖功能、小脑与认知功能以及交叉性小脑失联络。我们的目的是阐明小脑在认知神经脑网络中的作用和机制。
