Nakatani Satoru, Ebihara Nobuyuki, Murakami Akira
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Jpn J Ophthalmol. 2007 Nov-Dec;51(6):474-6. doi: 10.1007/s10384-007-0476-8. Epub 2007 Dec 21.
To evaluate the contribution of stem cell factor (SCF) to the pathogenesis of vernal keratoconjunctivitis (VKC), we determined levels of soluble SCF in the tear fluid of VKC patients.
Samples of tear fluid were obtained from 38 VKC patients and 13 normal controls after we received informed consent from each participant. In the 38 VKC patients, disease severity was mild in 13, moderate in 17, and severe in 8. The levels of soluble SCF in tear fluid were determined by enzyme immunoassay.
Mean +/- SD SCF levels in tears were 90.3 +/- 23.4 pg/ml in patients with mild VKC, 225.3 +/- 101.2 pg/ml in those with moderate VKC, and 872.0 +/- 313.2 pg/ml in those with severe VKC, and 68.3 +/- 15.3 pg/ml in healthy controls. The increase in SCF levels in patients with moderate or severe VKC was statistically significant compared with the level in healthy controls.
Soluble SCF may make a crucial contribution to the pathogenesis of VKC.
为评估干细胞因子（SCF）在春季角结膜炎（VKC）发病机制中的作用，我们测定了VKC患者泪液中可溶性SCF的水平。
在获得每位参与者的知情同意后，从38例VKC患者和13名正常对照者中获取泪液样本。在38例VKC患者中，13例病情为轻度，17例为中度，8例为重度。采用酶免疫测定法测定泪液中可溶性SCF的水平。
轻度VKC患者泪液中SCF的平均水平为（90.3±23.4）pg/ml，中度VKC患者为（225.3±101.2）pg/ml，重度VKC患者为（872.0±313.2）pg/ml，健康对照者为（68.3±15.3）pg/ml。中度或重度VKC患者的SCF水平与健康对照者相比，差异有统计学意义。
可溶性SCF可能在VKC的发病机制中起关键作用。
