Buchmann Inga, Riedmüller Karen, Hoffner Simone, Mack Ulrich, Aulmann Sebastian, Haberkorn Uwe
Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany.
Cancer Biother Radiopharm. 2007 Dec;22(6):779-89. doi: 10.1089/cbr.2007.358.
Breast carcinomas express the Na(+)/I() symporter and may-albeit not a routine procedure-be imaged with (123)iodide ((123)I) and (99m)technetium-pertechnetate ((99m)TcO(4)(-)) scintigraphy. The aim of our prospective study was the comparison of (99m)TcO(4)(-)--and (123)I-single-photon emission computed tomography (SPECT) with (18)F-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) in patients suspicious for breast cancer.
Twenty-nine (29) untreated patients suspected of having breast carcinoma were prospectively examined with thorax SPECT with (99m)TcO(4)(-) (n=19) or (123)I (n=10), respectively, and FDG-PET (n=29) prior to biopsy. Tumor-to-background ratios (TBRs) were calculated for SPECT findings. Mean and maximum standardized uptake values (SUVs) were calculated for PET findings. Findings were compared in an intra-individual lesion-to-lesion analysis.
In 28 of 29 patients, malignancy was verified with histopathology. In imaging the primary tumor, sensitivities of (99m)TcO(4)(-)-SPECT, (123)I-SPECT, and FDG-PET were 63%, 67%, and 89%, respectively. TBR maximum was 2.6+/-1.1 in (99m)TcO(4)()-SPECT and 2.3+/-0.6 in (123)I-SPECT. In FDG-PET, mean tumor SUV was 4.1+/-4 and maximum tumor SUV was 5.4+/-5.1. In contrast to FDG-PET, (99m)TcO(4)()-SPECT was ineffective in imaging nodal and distant metastases in the thorax, and (123)I-SPECT failed in imaging lymph node infiltrations. Distant metastases were not present in patients of the (123)I group, and the value of (123)I-SPECT was not evaluated.
In contrast to FDG-PET, (99m)TcO(4)(-) and (123)I-SPECT are ineffective in imaging breast carcinoma in clinical practice.
乳腺癌表达钠/碘同向转运体，或许可以用（123）碘（（123）I）和（99m）锝高锝酸盐（（99m）TcO4-）闪烁扫描成像，尽管这并非常规检查方法。我们前瞻性研究的目的是比较（99m）TcO4-和（123）I单光子发射计算机断层扫描（SPECT）与（18）F-2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）在疑似乳腺癌患者中的应用。
29例未经治疗的疑似乳腺癌患者，分别前瞻性地接受了胸部SPECT检查，其中（99m）TcO4-组19例，（123）I组10例，活检前均接受了FDG-PET检查（n = 29）。计算SPECT检查结果的肿瘤与本底比值（TBRs）。计算PET检查结果的平均和最大标准化摄取值（SUVs）。在个体内病变间分析中比较检查结果。
29例患者中有28例经组织病理学证实为恶性肿瘤。在对原发肿瘤成像时，（99m）TcO4-SPECT、（123）I-SPECT和FDG-PET的敏感性分别为63%、67%和89%。（99m）TcO4-SPECT的最大TBR为2.6±1.1，（123）I-SPECT为2.3±0.6。在FDG-PET中，肿瘤平均SUV为4.1±4，肿瘤最大SUV为5.4±5.1。与FDG-PET相比，（99m）TcO4-SPECT对胸部淋巴结及远处转移灶成像效果不佳，（123）I-SPECT对淋巴结浸润成像失败。（123）I组患者无远处转移，未评估（123）I-SPECT的价值。
与FDG-PET相比，（99m）TcO4-和（123）I-SPECT在临床实践中对乳腺癌成像效果不佳。
