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锌、铜和铁在巴基斯坦心肌梗死(首次、第二次和第三次心脏病发作)患者及对照组生物样本中的分布情况。

Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls.

作者信息

Kazi Tasneem Gul, Afridi Hassan Imran, Kazi Naveed, Jamali Mohammad Khan, Arain Mohammad Bilal, Sarfraz Raja Adil, Jalbani Nusrat, Ansari Rehana, Shah Abdul Qadir, Memon Ateeq-Ur-Rehman, Khandhro Ghulam Abbass

机构信息

National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan.

出版信息

Clin Chim Acta. 2008 Mar;389(1-2):114-9. doi: 10.1016/j.cca.2007.12.004. Epub 2007 Dec 14.

Abstract

BACKGROUND

The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. We examined the association of iron, copper and zinc between biological samples (scalp hair, whole blood and urine) and mortality from myocardial infarction (MI) patients of (first, second and third heart attack).

METHODS

The biological samples were from 130 MI patients (77 male and 53 female, age range 45-60 years) and 61 healthy age-matched controls (33 male and 28 female). The metals in the biological samples were measured by the flame atomic absorption spectrophotometry, prior to microwave assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials.

RESULTS

During this study, 78% of the 32 patients aged >50 years, registered after the third MI attack died. In these subjects the concentration of Fe and Cu were increased by 0.83% and 3.12% in the scalp hair while in blood samples 9.7% and 22.5% were enhanced respectively, as compared to those who tolerated 3rd MI attack (p=0.072). The concentrations of Zn in whole blood and scalp hair samples were lower in MI patients as compared to normal subjects.

CONCLUSION

Deficiency of zinc and high concentration of copper and iron may play a role in the development of heart disease.

摘要

背景

某些心脏病的发病机制与特定微量元素平衡的变化有关。我们研究了生物样本(头发、全血和尿液)中的铁、铜和锌与首次、第二次和第三次心脏病发作的心肌梗死(MI)患者死亡率之间的关联。

方法

生物样本来自130例MI患者(77例男性和53例女性,年龄范围45 - 60岁)和61例年龄匹配的健康对照(33例男性和28例女性)。在微波辅助酸消解之前,通过火焰原子吸收分光光度法测量生物样本中的金属含量。通过生物认证参考物质检查该方法的有效性。

结果

在本研究期间,第三次MI发作后登记的32例年龄>50岁的患者中,78%死亡。与耐受第三次MI发作的患者相比,这些受试者头发中的铁和铜浓度分别增加了0.83%和3.12%,而血液样本中分别增加了9.7%和22.5%(p = 0.072)。与正常受试者相比,MI患者全血和头发样本中的锌浓度较低。

结论

锌缺乏以及铜和铁的高浓度可能在心脏病的发展中起作用。

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