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西罗莫司洗脱支架植入术后接受噻氯匹定和阿司匹林治疗的患者发生晚期支架血栓形成。

Late stent thrombosis in patients receiving ticlopidine and aspirin after sirolimus-eluting stent implantation.

作者信息

Kitahara Hideki, Kobayashi Yoshio, Fujimoto Yoshihide, Nakamura Yoshitake, Nakayama Takashi, Kuroda Nakabumi, Himi Toshiharu, Miyazaki Akira, Komuro Issei

机构信息

Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

出版信息

Circ J. 2008 Jan;72(1):168-9. doi: 10.1253/circj.72.168.

DOI:10.1253/circj.72.168
PMID:18159121
Abstract

BACKGROUND

There is little information about the efficacy of ticlopidine plus aspirin after sirolimus-eluting stent (SES) implantation.

METHODS AND RESULTS

The incidence of stent thrombosis was evaluated in 1,029 patients receiving ticlopidine and aspirin after SES deployment. Clinical follow-up was obtained in 98.9% (mean follow-up 17.0+/-7.9 months). Early stent thrombosis was observed in 5 patients (0.49%). There was 1 case each of late (0.1%) and very late stent thrombosis (0.1%).

CONCLUSION

Late and very late stent thrombosis in Japanese patients receiving ticlopidine and aspirin after SES deployment occurs infrequently.

摘要

背景

关于西罗莫司洗脱支架(SES)植入后噻氯匹定联合阿司匹林的疗效信息较少。

方法与结果

对1029例SES植入后接受噻氯匹定和阿司匹林治疗的患者评估支架血栓形成的发生率。98.9%的患者获得了临床随访(平均随访17.0±7.9个月)。5例患者(0.49%)发生早期支架血栓形成。晚期(0.1%)和极晚期支架血栓形成各有1例(0.1%)。

结论

日本患者在SES植入后接受噻氯匹定和阿司匹林治疗时,晚期和极晚期支架血栓形成发生率较低。

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Heart Vessels. 2014 Jan;29(1):1-6. doi: 10.1007/s00380-012-0318-6. Epub 2012 Dec 30.
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Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study.与200毫克噻氯匹定相比,氯吡格雷50毫克维持剂量的抗血小板作用:一项初步研究。
Heart Vessels. 2010 Jan;25(1):41-4. doi: 10.1007/s00380-009-1165-y. Epub 2010 Jan 21.