Markowska Janina
Katedra Onkologii Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
Ginekol Pol. 2007 Sep;78(9):715-8.
IMeasurement of tumor markers level in human body fluids, mainly in serum may be useful for diagnosis, therapy monitoring and early recurrence detection. SCC-Ag, Cyfra 21-1, CEA, CA 125 and TPS are of a clinical value in uterine cervical cancer despite their diverse significance. Other biological markers that could be measured in serum as well as in tumor tissue are cytokines: VEGF, IL-6, IL-8, IL-4, IL-10, leptin, stromal drive factor (SDF- 1), although assessment of their importance needs further examination. Elevation of uterine cervical cancer hypoxia markers such as HIF 1a, CA 9, GLUT-1 is combined with poorer clinical outcome prognosis.
检测人体体液（主要是血清）中的肿瘤标志物水平可能有助于诊断、治疗监测和早期复发检测。鳞状细胞癌抗原（SCC-Ag）、细胞角蛋白19片段（Cyfra 21-1）、癌胚抗原（CEA）、糖类抗原125（CA 125）和组织多肽特异性抗原（TPS）在子宫颈癌中具有临床价值，尽管它们的意义各不相同。其他可在血清以及肿瘤组织中检测的生物标志物是细胞因子：血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-4（IL-4）、白细胞介素-10（IL-10）、瘦素、基质衍生因子-1（SDF-1），不过对它们重要性的评估还需要进一步研究。子宫颈癌缺氧标志物如缺氧诱导因子1α（HIF 1α）、碳酸酐酶9（CA 9）、葡萄糖转运蛋白1（GLUT-1）的升高与较差的临床结局预后相关。
