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肾移植术后患者血清骨钙素和β-交联羧基末端肽浓度

[Blood serum osteocalcin and beta-crosslaps concentrations in patients after renal transplantation].

作者信息

Zbróg Zbigniew, Tomaszek Małgorzata, Szuflet Adam, Pierzchalska-Mudyna Teresa, Rybińska Agnieszka, Skrzypek Agnieszka, Matych Józef

机构信息

Oddział Nefrologii WSS im. M. Kopernika, Łódź.

出版信息

Przegl Lek. 2007;64(6):431-4.

Abstract

In 16 patients (7 males, 9 females), aged 47.2 +/- 15.9 years, blood serum concentrations of osteocalcin, beta-crosslaps, parathormone, calcium, phosphate, creatinine and urea were determined before renal transplantation and 3 and 6 months following the procedure. Three as well as six months following renal transplantation significant decrease in blood serum concentration of osteocalcin and beta-crosslaps are found. A significant positive correlation between osteocalcin and beta-crosslaps concentration was found in each investigated period. Six-months observation revealed only partial correction of bone metabolism following renal transplantation.

摘要

对16例患者(7例男性,9例女性)进行了研究,患者年龄为47.2±15.9岁,在肾移植前以及肾移植术后3个月和6个月测定了血清骨钙素、β-交联羧基末端肽、甲状旁腺激素、钙、磷、肌酐和尿素的浓度。肾移植术后3个月和6个月时,血清骨钙素和β-交联羧基末端肽的浓度均显著下降。在每个研究阶段,骨钙素和β-交联羧基末端肽浓度之间均存在显著正相关。6个月的观察结果显示,肾移植术后骨代谢仅得到部分纠正。

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