甲状腺激素对大鼠垂体肿瘤细胞生长的调节：脱铁转铁蛋白作为自分泌甲状腺介质的新作用。

Thyroid hormone regulation of rat pituitary tumor cell growth: a new role for apotransferrin as an autocrine thyromedin.

作者信息

Sirbasku D A, Pakala R, Sato H, Eby J E

机构信息

Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225.

出版信息

Mol Cell Endocrinol. 1991 May;77(1-3):C47-55. doi: 10.1016/0303-7207(91)90053-u.

DOI:10.1016/0303-7207(91)90053-u

PMID:1815990

Abstract

In the 40 years of transferrin research, no previous role for apotransferrin has been recognized other than to serve as a plasma carrier for dietary and storage iron. Our studies have revealed a new 'autocrine' growth role for this molecule as well as a possible new cell-cell bridge/CAM function. Certainly, these observations have opened many new areas of investigation both with regard to thyroid hormone action and the function of apotransferrin. In addition, there is now accessible the broader question of tissues other than pituitary which might utilize apotransferrin to regulate responsiveness to thyroid hormones.

摘要

在转铁蛋白研究的40年里，除了作为膳食铁和储存铁的血浆载体外，脱铁转铁蛋白以前未被认识到有其他作用。我们的研究揭示了这种分子新的“自分泌”生长作用以及可能的新的细胞间桥梁/细胞黏附分子功能。当然，这些观察结果在甲状腺激素作用和脱铁转铁蛋白功能方面都开辟了许多新的研究领域。此外，现在有一个更广泛的问题可供探讨，即除垂体外的其他组织是否可能利用脱铁转铁蛋白来调节对甲状腺激素的反应性。