Coban Erkan, Aydemir Mustafa
Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Med Sci Monit. 2008 Jan;14(1):CR42-46.
During the last 15 years, several risk markers for atherosclerosis, such as fibrinogen and D-dimer, have been identified. The role of elevated fibrinogen levels as an independent risk factor for coronary, cerebral, and peripheral vascular disease is well established on the basis of clinical and epidemiological studies. Increased D-dimer levels are associated with increased risk of future myocardial infarction, stroke, and peripheral vascular disease. The aim of this study was to evaluate the alterations in fibrinogen and D-dimer, which indicates overall thrombotic activity, in subjects with subclinical hyperthyroidism.
MATERIAL/METHODS: Thirty-six subclinical hyperthyroidic subjects and 36 euthyroidic control subjects matched for age, gender, and body mass index were selected. The levels of plasma fibrinogen and D-dimer in all subjects were measured.
The level of fibrinogen was significantly higher in the subclinical hyperthyroidic group than in the euthyroidic group (296.9+/-74.3 mg/dl vs. 255.0+/-41.7 mg/dl, p<0.001). The level of D-dimer was significantly higher in the subclinical hyperthyroidic group than in the euthyroidic group (261.9+/-47.8 mg/dl vs. 216.4+/-32.1 mg/dl, p<0.000).
The results suggest that subjects with subclinical hyperthyroidism present a relatively hypercoagulable state. This state could contribute to increased thromboembolic risk in subclinical hyperthyroidism.
在过去15年中，已确定了几种动脉粥样硬化的风险标志物，如纤维蛋白原和D-二聚体。基于临床和流行病学研究，纤维蛋白原水平升高作为冠状动脉、脑血管和外周血管疾病的独立危险因素的作用已得到充分确立。D-二聚体水平升高与未来心肌梗死、中风和外周血管疾病风险增加相关。本研究的目的是评估亚临床甲状腺功能亢进患者中表明总体血栓形成活性的纤维蛋白原和D-二聚体的变化。
材料/方法：选取36例亚临床甲状腺功能亢进患者和36例年龄、性别和体重指数相匹配的甲状腺功能正常的对照者。测量所有受试者的血浆纤维蛋白原和D-二聚体水平。
亚临床甲状腺功能亢进组的纤维蛋白原水平显著高于甲状腺功能正常组（296.9±74.3mg/dl对255.0±41.7mg/dl，p<0.001）。亚临床甲状腺功能亢进组的D-二聚体水平显著高于甲状腺功能正常组（261.9±47.8mg/dl对216.4±32.1mg/dl，p<0.000）。
结果表明，亚临床甲状腺功能亢进患者呈现相对高凝状态。这种状态可能导致亚临床甲状腺功能亢进患者血栓栓塞风险增加。
